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A comprehensive collection of research articles, scientific papers, and relevant publications produced by the Breast Health Working Group International, providing valuable insights and contributing to the global knowledge base in the field of breast health and breast cancer research. 1.   18F-FDG PET/CT in Early Stage Breast Cancer Comes with Financial Burden. https://www.facs.org/for-medical-professionals/news-publications/news-and-articles/bulletin/2024/julyaugust-2024-volume-109-issue-7/18f-fdg-petct-in-early-stage-breast-cancer-comes-with-financial-burden/. Atilla Soran, MD, MPH, FACS, Mehmet Ali Nazlı, MD, Osman Toktas, MD, and Serdar Ozbas, MD, FEBS 2.   Intervention for Hepatic and Pulmonary Metastases in Breast Cancer Patients: Prospective, Multi-instutional Registry Study-IMET, Protocol MF 14-02. https://pubmed.ncbi.nlm.nih.gov/35876920/ Soran et al. Annals of Surgical Oncology volume 29, pages6327–6336 (2022). The surgical resection or ablative interventions may contribute to the survival of breast cancer patients with a limited number and operable metachronous hepatic/pulmonary metastases. 3.   Locoregional Therapy for Intact Primary Tumor in De Novo Stage IV Breast Cancer. https://pubmed.ncbi.nlm.nih.gov/35820106/. Soran et al. Correspondence. Journal of Clinical Oncology 2022 40:33, 3897-3898 https://doi.org/10.1200/JCO.22.00802. In light of this discussion, we shared our concerns that the LRT does not provide a survival advantage in dn stage IV BC. 4.   The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study. https://pubmed.ncbi.nlm.nih.gov/33532878/ Soran et al. Ann Surg Oncol​. 2021 Sep;28(9):5048-5057. doi: 10.1245/s10434-021-09621-8. Epub 2021 Feb 2. The LRT prolonged overall survival and SPFS and decrease locoregional recurrence in a median 3 year follow up. Timing of primary breast surgery either at diagnosis or after ST provided a similar survival benefit compare with ST alone in de novo stage IV BOM BC patients.  5.   Correspondence to ‘’ Locoregional therapy in de novo metastatic breast cancer: Systematic review and meta-analysis, written by Reinhorn D et al. https://pubmed.ncbi.nlm.nih.gov/34654601/  In The Breast Journal 58 (2021) 173-181’’. Soran et al. In The Breast Journal 58 (2021) 173e181”, The Breast, https://doi.org/10.1016/j.breast.2021.10.002. There is a group of patients, such as having low tumor burden and bone metastatic group, has a survival benefit when cautiously evaluated for primary breast surgery in de novo stage IV BC. 6.   The role of loco-regional treatment in long-term quality of life in de novo stage IV breast cancer patients: protocol MF07-01Q. https://pubmed.ncbi.nlm.nih.gov/33242163/.     Soran et al. Supportive Care in Cancer, Springer 2020, DOI 10.1007/s00520-020-05905-z. Patient who had LRT has similar physical and mental health outcomes compared to ST only in a cohort of patients who lived longer than three years. 7.   A Novel First-Line Treatment Alternative for Noncomplicated Idiopathic Granulomatous Mastitis: Combined Intralesional Steroid Injection with Topical Steroid Administration. https://pubmed.ncbi.nlm.nih.gov/34012373/ Toktas et al. Breast Care 2021;16:181–187 DOI: 10.1159/000507951. The comparison between the efficacy of combined intralesional  steroid injection with topical steroid administration to systemic streoid therapy in the treatment of noncomplicated IGM. 8.   Loco-Regional Treatment for Intact Primary Tumor in Patient with De Novo Metastatic Breast Cancer; Comments and Concerns of ECOG-ACRIN 2018 Trial. https://pubmed.ncbi.nlm.nih.gov/32656512/ Soran et al.Eur J Breast Health 2020; 16(3): 158-159DOI: 10.5152/ejbh.2020.080620. It is important to achieve local control in oligometastatic cases, especially in patients with bone only metastases. In addition, surgical removal of the primary tumor is important to prevent local spread to the pleura and pericardium. 9.   Are we close to the end of primary tumor resection discussion for de novo stage IV BC? https://pubmed.ncbi.nlm.nih.gov/30528045/  A.Soran, European Journal of Surgical Oncology (2018), https://doi.org/10.1016/j.ejso.2018.09.022. LRT should be considered in selected cases; oncologists must consider age, performance status, comorbidities, tumor type, and metastatic disease burden while discussing LRT with patients. 10.                Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01. https://pubmed.ncbi.nlm.nih.gov/29777404/ Soran et al. Ann Surg Oncol. 2018 Oct;25(11):3141-3149. doi: 10.1245/s10434-018-6494-6.  The first randomized controlled trial in denovo metastatic breast cancer. 11.                Factors related to recurrence of idiopathic granulomatous mastitis what do we learn from a multicentre study? https://pubmed.ncbi.nlm.nih.gov/29777404/  Uysal et al. doi: 10.1111/ans.14115. Having a history of pregnancy, breastfeeding, breast infection, and smoking increases the risk of IGM recurrence. However, the treatments examined in this study did not affect the recurrence of IGM. 12.                ASO Author Reflections: Is Intensifying Loco-Regional treatment In the Early Course of De Novo Stage IV Breast Cancer Reasonable? https://pubmed.ncbi.nlm.nih.gov/30357577/  The evolution of LRT to BC from past to future. A.Soran, A brief invited commentary on the article. 13.                Validation of breast cancer nomograms for predicting the non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in a multi-center study. https://pubmed.ncbi.nlm.nih.gov/19535217/ Gur et al.2009 Elsevier, doi:10.1016/j.ejso.2009.05.007. Various nomograms were assessed to detect non-sentinel lymph node metastasis (NSLNM) in breast cancer patients with positive sentinel lymph nodes (SLN).

Title
Publication date
Summary
Journal
A Pragmatic Grouping Model for Bone-Only De Novo Metastatic Breast Cancer (MetS Protocol MF22-03)
2025
New subgrouping reveals which dnBOMBC patients truly benefit from multimodal therapy.
Cancers 2025, DOI: 10.3390/cancers17122033
Loco-Regional Treatment in De Novo Bone Only Metastatic Breast Cancer; Prospective, Multi-Institutional Real-World Data, BOMETIN, Protocol MF14-1a
2025
The most recent and a very large international study of 744 patients shows that LRT significantly improves survival in de novo bone-only metastatic breast cancer, benefiting both solitary and multiple bone metastasis subgroups.
Current Oncology
Biologically Informed Decision-Making for PMRT in pT3N0M0 Luminal Breast Cancers (Protocol MF22-02): International Multicenter Real-World Data
2025
Magee Score guides safe omission of PMRT in select luminal breast cancer patients
Clin Breast Cancer 2025, DOI: 10.1016/j.clbc.2025.04.012
18F-FDG PET/CT in Early Stage Breast Cancer Comes with Financial Burden
2024
Discusses financial implications of PET/CT in early-stage breast cancer.
FACS Bulletin, 2024, https://www.facs.org/for-medical-professionals/news-publications/news-and-articles/bulletin/2024/julyaugust-2024-volume-109-issue-7/18f-fdg-petct-in-early-stage-breast-cancer-comes-with-financial-burden/
Navigating Lymphedema: The Impact of Indocyanine Green Lymphography on Personalized Therapy Outcomes in Breast Cancer Patients
2024
Personalized, ICG-guided therapy prevents progression of breast cancer–related lymphedema and improves long-term outcomes.
Clin Breast Cancer. Published online October 18, 2024. doi:10.1016/j.clbc.2024.10.010
Intervention for Hepatic and Pulmonary Metastases in Breast Cancer Patients: Prospective, Multi-institutional Registry Study-IMET, Protocol MF 14-02
2022
Evaluates survival benefits of resection or ablation in patients with operable hepatic/pulmonary metastases.
Ann Surg Oncol. 2022;29(10):6327-6336. doi:10.1245/s10434-022-12239-z
Locoregional Therapy for Intact Primary Tumor in De Novo Stage IV Breast Cancer
2022
Examines LRT in Stage IV breast cancer, suggesting no survival advantage.
J Clin Oncol. 2022;40(33):3897-3898. doi:10.1200/JCO.22.00802
A Novel First-Line Treatment Alternative for Noncomplicated Idiopathic Granulomatous Mastitis: Combined İntralesional Steroid İnjection with Topical Steroid Administration
2021
Compares combined steroid treatments to systemic therapy in IGM patients.
Breast Care (Basel). 2021;16(2):181-187. doi:10.1159/000507951
The role of loco-regional treatment in long-term quality of life in de novo stage IV breast cancer patients: protocol MF07-01Q
2021
Analyzes LRT's impact on QoL, noting similar outcomes compared to systemic therapy.
Support Care Cancer. 2021;29(7):3823-3830. doi:10.1007/s00520-020-05905-z
ASO Author Reflections: Locoregional Therapy in De Novo Bone-Only Metastatic Breast Cancer Provides Survival Advantage Regardless of Therapy Sequencing
2021
Commentary on LRT's evolution in breast cancer treatment.
Ann Surg Oncol. 2021;28(9):5058. doi:10.1245/s10434-021-09664-x
The Effect of Primary Surgery in Patients with De Novo Stage IV Breast Cancer with Bone Metastasis Only (Protocol BOMET MF 14-01): A Multi-Center, Prospective Registry Study
2021
Reports LRT benefits, showing survival improvement in bone-only metastasis cases.
Ann Surg Oncol. 2021;28(9):5048-5057. doi:10.1245/s10434-021-09621-8
Correspondence to "Locoregional therapy in de novo metastatic breast cancer: Systematic review and meta-analysis, written by Reinhorn D et al. In The Breast Journal 58 (2021) 173-181"
2021
Suggests potential survival benefits for selected patients with low tumor burden.
The Breast Journal 58 (2021) 173-181". Breast. 2021;60:304-305. doi:10.1016/j.breast.2021.10.002
Loco-Regional Treatment for Intact Primary Tumor in Patient with De Novo Metastatic Breast Cancer; Comments and Concerns of ECOG-ACRIN 2108 Trial
2020
Highlights LRT importance in local control for bone-only metastasis cases.
Eur J Breast Health. 2020 Jun 8;16(3):158-159. doi: 10.5152/ejbh.2020.080620. PMID: 32656512; PMCID: PMC7337916.
Are we close to the end of the primary tumor resection discussion for de novo stage IV BC?
2018
Discusses selective cases where LRT may be beneficial.
Eur J Surg Oncol. 2019;45(2):81-82. doi:10.1016/j.ejso.2018.09.022
Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01
2018
First RCT in metastatic breast cancer, comparing resection and non-surgical options.
Ann Surg Oncol. 2018;25(11):3141-3149. doi:10.1245/s10434-018-6494-6
Factors Related to Idiopathic Granulomatous Mastitis Recurrence
2018
Identifies factors affecting IGM recurrence, including breastfeeding and smoking.
ANZ J Surg. 2018;88(6):635-639. doi:10.1111/ans.14115
Validation of breast cancer nomograms for predicting the non-sentinel lymph node metastases after a positive sentinel lymph node biopsy in a multi-center study
2010
Assesses nomograms for detecting metastasis in non-sentinel lymph nodes.
Eur J Surg Oncol. 2010;36(1):30-35. doi:10.1016/j.ejso.2009.05.007
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